The DEPARTURE study showed that the 12-month salvage rate after percutaneous deep venous arterialization (pDVA) with endovascular therapy (EVT) was more than 70% in Japanese patients with no-option chronic limb-threatening ischemia (CLTI), according to Dr. Tatsuya Nakama et al. from the Tokyo Bay Medical Center as reported in the online edition of CardioVascular and Interventional Radiology, March 2022.
Clinical Outcomes of pDVA with Ordinary EVT Devices in Patients with CLTI after 12-Months: Results of the DEPARTURE Study in Japan
Dr. Nakama et al. evaluated the clinical outcomes of 18 Japanese CLTI patients (18 limbs, mean age 75.5 years, 14 male) who underwent pDVA from January 2016 to November 2020 with no other treatment options.
Of the patients, 14 (77.8%) had diabetes, 6 (33.3%) were non-ambulatory, 16 (88.9%) were on dialysis, 15 (83.3%) had wound, ischemia, and foot infection (WIfI) stage 4, 33.7% were Rutherford class 5 and 66.7% were Rutherford class 6. The technical success rate for pDVA was 88.9%. The 6-month and 12-month salvage rates were 72.2% and 72.2%, while amputation-free survival rates were 55.6% and 49.4%, and complete wound healing rates were 23.0% and 53.2%, respectively. The median time to complete wound healing was 234 days.
Dr. Nakama et al. summarized, “The DEPARTURE study has demonstrated acceptable safety and efficacy in Japanese patients with CLTI, and pDVA can be considered as an option before major amputation in CLTI patients who have no other options.”
Nakama T, et al. Cardiovasc Intervent Radiol. 2022; in press
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