From the J-CONFIRM registry, patients aged ≥75 years and those aged <75 years had similar risk of ischemic events related to coronary artery lesions, as defers based on FFR, Dr. Yasushi Ueki of Shinshu University School of Medicine et al. reported in the September issue of Circulation Journal.
Long-term Outcomes in Elderly Patients Deferring FFR Guided Coronary Revascularization: The J-CONFIRM Registry
Dr. Ueki and colleagues studied 1,262 patients enrolled in the J-CONFIRM registry, divided into two groups according to age: ≥75 years (older group) and <75 years (younger group), with 5-year TVF (composite of cardiac death, MI related to target vessel, and clinically derived TVR) as the primary endpoint.
The 5-year TVF rate was not significantly different between the older and younger groups (14.3% vs 10.8%: p=0.12). Cardiac death was more frequent in the older group compared to the younger group (4.4% vs 0.8%: p<0.001), but there were no differences between the two groups for MI related to the target vessel (1.3% vs 0.9%: p=0.80) and TVR of clinical origin (10.7% vs 10.1%: p=0.80). Mean FFR values for lesions with <50% diameter stenosis were significantly higher in the older group compared to the younger group (0.88 vs 0.85: p=0.01), but no such difference was observed for diameter stenosis ≥50% (0.86 vs 0.85: p=0.23).
Dr. Ueki and colleagues summarized, "Although there was no increased risk of ischemic events associated with lesions deferred by FFR in older patients, the FFR value for mild coronary stenosis was slightly higher than in younger patients."
Ueki Y, et al. Circ J. 2022; 86: 1329-1336
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