[2022/10/27]One-year follow-up of the multicenter DISRUPT CAD IV trial in Japan showed that the risk of MACE (cardiac death, MI, TVR) and TLF (cardiac death, MI related to target vessel, TLR) was low one year after intravascular lithotripsy (IVL) and stenting of highly calcified lesions in the coronary arteries, according to a report by Dr. Shigeru Saito of Shonan-Kamakura General Hospital and colleagues reported in the September issue of Circulation Reports.
Intravascular Lithotripsy as Vessel Preparation Prior to Stenting for Calcified Coronary Artery Lesions: The DISRUPT CAD IV Trial
The DISRUPT CAD IV trial enrolled 72 patients treated with IVL for highly calcified coronary lesions with target lesion length ≦40 mm and reference diameter 2.5-4.0 mm at eight centers in Japan from November 2019 to April 2020. After excluding patients initially enrolled at each center, 64 patients were included in the intention-to-treat analysis, and all patients were followed for 1 year.
All patients underwent successful coronary IVL and stenting; 1-year MACE rate was 9.4% (0 cardiac death, 6.3% MI, 4.7% TVR); TLF was observed in 6.3% and was attributed to non-Q-wave MI (6.3%); 1-year TLR rate was 1.6%; no stent thrombosis.
Dr. Saito and colleagues summarized, "Treatment of highly calcified lesions in Japanese patients with IVL showed a low 1-year risk of MACE and TLR, demonstrating the continued safety and efficacy of stenting coronary arteries with IVL.
Saito S, et al. Circ Rep. 2022; 4: 399-404
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